Research

The Jiang Lab builds technologies to fuel new discovery in the microbial world. Over the last decade, Dr. Jiang has developed novel technologies that enhance the precision, throughput and resolution for bacterial genomics and transcriptomics. These include development of the first CRISPR-Cas9 genome editing and gene expression modulation technology in bacteria, a high-throughput bacterial functional genomic platform called CALM, and the first bacterial high-throughput single-cell RNA sequencing (scRNA-seq) technology called PETRI-seq. Adopted by many labs around the world, these technologies have substantially expanded scientists’ ability to solve fundamental and applied questions in complex microbial systems.

One long-term goal of the Jiang Lab is to continue developing enabling technologies such as CRISPR genome editing, functional genomics and various single-cell tools, and expanding them to a wide range of clinically and industrially important non-model bacterial species that are traditionally hard to manipulate.

By applying these technologies, we aim to tackle systems-level problems in microbiology, such as understanding genetic interaction networks, evolution, microbial heterogeneity, microbe-phage, and host-microbe interactions. The fundamental principles we learn from these studies could then help us develop more effective antimicrobial drugs, and engineer commensal bacteria to promote human health.

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